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doi: 10.3899/jrheum.130367 13 KomaroffALLipkinWI

Diabetes Investig

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While IGF-1 has important physiological functions, elevated levels carry potential concerns including increased cell proliferation that may support tumor growth in individuals with cancer or pre-cancerous conditions, accelerated aging processes through growth pathway activation, potential cardiovascular effects with chronic elevation, and metabolic consequences including effects on glucose and lipid metabolism